Malaria Vaccine R&D

Therapies are available for malaria patients, but the worsening problem of drug resistance in many parts of the world is making adequate treatment and control of malaria increasingly difficult. Therapies are available for malaria patients, but the worsening problem of drug resistance in many parts of the world is making adequate treatment and control of malaria increasingly difficult. Copyright Crucell

What are the health needs and challenges?

There is currently no licensed vaccine to protect people against malaria, a disease caused by infection with the Plasmodium parasite and transmitted by mosquitoes. Therapies are available for malaria patients, but the worsening problem of drug resistance in many parts of the world is making adequate treatment and control of malaria increasingly difficult. In addition, many insecticides are no longer useful against the mosquitoes that transmit the disease.

Description of partnership activities and how they address needs and challenges

Crucell’s first collaboration aimed at malaria vaccine research was born in March 2003, with the Walter Reed Army Institute of Research (WRAIR) and GlaxoSmithKline Biologicals (GSK). In a collaborative preclinical study, a candidate Ad35.CS malaria vaccine as a stand-alone vaccine and in combination with GSK’s RTS,S malaria vaccine candidate was tested. These studies showed that Crucell’s AdVac® vaccine efficiently primed and/or boosted malaria-specific immune responses. 

Partnership information

Company(ies) GlaxoSmithKline

Partner(s) PATH Malaria Vaccine Initiative (MVI), US Agency for International Development (USAID), US National Institutes of Health (NIH), Walter Reed Army Institute of Research

Type of Partner(s) Academia / Hospitals, Government, PDPs

Therapeutic Focus Infectious Diseases

Disease(s) Malaria

Program Type(s) Prevention Programs - Vaccines, Research & Development - Development of Treatments

Targeted Population(s) Children, People with low income

Region(s) East Asia & Pacific, South Asia, Sub-Saharan Africa

Number of Countries 63

Country(ies) Angola, Bangladesh, Benin, Bhutan, Botswana, Burkina Faso, Burundi, Cameroon, Cape Verde, Central African Republic, Chad, China, Comoros, Congo, Côte d'Ivoire, Democratic Republic of the Congo, Equatorial Guinea, Eritrea, Ethiopia, Gabon, Ghana, Guinea, Guinea-Bissau, India, Indonesia, Kenya, Lao PDR, Lesotho, Liberia, Madagascar, Malawi, Malaysia, Mali, Mauritania, Mauritius, Mozambique, Myanmar, Namibia, Nepal, Niger, Nigeria, Pakistan, Papua New Guinea, Philippines, Rwanda, Sao Tome and Principe, Senegal, Seychelles, Sierra Leone, Somalia, South Africa, South Sudan, Sri Lanka, Sudan, Swaziland, Tanzania, Thailand, The Gambia, Togo, Uganda, Vietnam, Zambia, Zimbabwe

Research Country(ies) Burkina Faso, United States of America

Start Date 2003

More information Crucell website

Completed date 2012