Pfizer Antimicrobial Innovative Vaccines

Program Ojectives

The program aims to prevent initial infection by developping new vaccines. This will consequently reduce antibiotic use and the spread of AMR. 

What are the health needs and challenges?

Pfizer has made significant and substantial investments in vaccine R&D to develop new vaccines and to support several vaccines already in clinical usage.  It has been clearly demonstrated that bacterial vaccines significantly reduce AMR by preventing infection in the first place thus reducing the need to use antibiotics. In addition, bacterial vaccines if and when used to immunize large sections of a population also reduce the spread of AMR bacteria in the community through herd immunity.

Description of partnership activities and how they address needs and challenges

Pfizer Vaccines in Late – Stage Development

In 2015, Pfizer began enrolling patients in a Phase 2 clinical trial of our investigational Staphylococcus aureus vaccine, designed to prevent this widespread but increasingly drug-resistant bacterium. In addition, enrolment is complete in the Phase 2 program for the Pfizer Clostridium difficile vaccine, aimed at the bacteria responsible for nearly a half million infections resulting in 29,000 US deaths in 2011. Prevention would reduce this disease impact and the need to treat the infections with antibiotics hence reducing overall antibiotic use. Both of these vaccine candidates have received Fast Track designation from the FDA

Pfizer Vaccines in Early – Stage Development

In early stage development is a vaccine for protection against Group B Streptococcus (GBS). Treatment guidelines advise that GBS-colonized women should receive intrapartum antibiotic prophylaxis to prevent GBS disease in the neonate. Up to a million plus women each year are treated in this fashion.  The potential impact of antibiotic prophylaxis on both the microbiome of the newborn and the emergence of AMR is unknown; however, a vaccine against GBS would reduce the need for prophylactic antibiotic use and the potential for AMR.

Corresponding principle in the declaration

“We are investing in a range of innovative antibiotics, vaccines, alternative technologies, and diagnostics for resistant infections. We are advancing our pipelines, but more work and investment into multiple approaches is needed to overcome the significant scientific difficulties of antibiotic discovery”.

Read full Declaration by the Pharmaceutical, Biotechnology and Diagnostics Industries on Combating Antimicrobial Resistance (AMR)

Partnership information

Company(ies) Pfizer

Therapeutic Focus Infectious Diseases

Disease(s) Drug-Resistant Infections (AMR)

Program Type(s) Prevention Programs - Vaccines, Research & Development - Development of Treatments

Region(s)

Start Date 2015

More information Pfizer Research Vaccines

Anticipated completion date Ongoing