Sanofi Dengue Control

Partnership objectives

  1. Contribute to the scientific knowledge about dengue.
  2. Support the implementation of comprehensive preventive measures.

ASEAN Dengue Day 2013 ASEAN Dengue Day 2013 Copyright ASEAN

What are the health needs and challenges?

Dengue is a threat to nearly half of the world’s population. Currently, there is no specific treatment available for dengue. It is a public health concern in many countries of Latin America and Asia where epidemics occur regularly. The WHO estimates up to 390 million infections per year but the overall number of people infected with dengue globally is not fully known. The WHO has set the goal of estimating the true public health burden of dengue by 2015. Dengue is underreported because the disease is often misdiagnosed due to a large spectrum of clinical symptoms from mild non-specific illness to life threatening complications and because of the limitations of the surveillance systems.

Each year, 500,000 people, including children, are affected with dengue haemorrhagic fever (DHF), the severe form of the disease. DHF is a leading cause of hospitalization, placing tremendous pressure on health systems and straining medical resources resulting in significant economic and social impact. Timely access to appropriate health care is critical to reduce the risk of mortality in case of severe dengue. The WHO has set the target to reduce dengue mortality by 50% and reduce morbidity by 25% by 2020.

Description of partnership activities and how they address needs and challenges

Sanofi Pasteur is committed to supporting efforts in developing a comprehensive and multi-dimension approach to control the spread of Dengue disease.  Sanofi Pasteur is joining efforts with global international groups to develop an integrated, holistic approach to dengue control and to eliminate dengue as a public health problem. In addition, since 2013, Sanofi Pasteur is  participating in scientific collaborations with renowned research institutions for modelling dengue vaccination impact.

Sanofi Pasteur is also contributing to a series of initiatives from scientific seminars to community engagement activities and educational programs for school children to support the implementation of comprehensive preventive measures. This includes:

  • ASEAN Dengue Day (disease awareness and community engagement to help the public to identify and remove potential mosquito breeding sites, minimize exposure to mosquito bites and prevent dengue). Held every year on 15 June concurrently in all 10 member countries, ASEAN Dengue Day provides a common platform for cooperation and exchange among all stakeholders on raising dengue prevention and awareness.
  • Dengue Patrol Program in primary schools located in dengue hotspots together with Ministry of Education and Ministry of Health of Malaysia since 2011. The program aimed at educating students on dengue prevention and empowering them to take action in dengue prevention activities both at home and at school. The Dengue Patrol Program Since then, the program has expanded to a nationwide effort, involving more than 4,000 students in 170 schools across Malaysia. Sanofi Pasteur’s commitment is to continue the success of this campaign and broaden the reach of this program to include education and raising awareness on dengue prevention and management in 2015 and beyond in secondary school and universities.
  • A modelling consortium on dengue vaccination with researchers from Imperial College London and information sharing with Johns Hopkins University, the University of Florida and the Fred Hutchinson Center for Cancer Research.
  • The Dengue Vaccine Initiative a co-founder with the Partnership for Dengue Control (PDC) of the Global Dengue and Aedes-transmitted diseases Consortium (GDAC), in organizing a common review of the registration dossier by NRAs (national regulatory agencies) of early adopter countries with European experts selected by WHO and in the dengue preparedness plan elaborate by the MoH representatives attending dengue prevention boards in Asia and Latin America.
     
  • Break Dengue, a project to support Dengue prevention, advance science, and create shared value through social media because fighting Dengue requires an aggregated, mobilized community. By setting local chapters for engagement and initiatives like BD campaigning or BD globe trotter, this project aims at creating a global social movement against Dengue, to impact the disease by connecting all Dengue fighters.
     
  • The Dengue Voice a coalition of independent civil society organizations,  NGOs, Digital opinion leaders, Health care providers, dengue and/or public health specialists, etc.,  advocating for an holistic dengue prevention and for moving from vaccine to vaccination.

Videos

Sanofi Pasteur dengue vaccine candidate under study

Partnership information

Company(ies) Sanofi

Partner(s) Association of Southeast Asian Nations (ASEAN), Bloomberg School of Public Health, Johns Hopkins University, Fred Hutchinson Cener for Cancer Research, Imperial College London, International Vaccine Access Center, International Vaccine Institute, Local government & associations, Malaysian Minsitry of Health, Partnership for Dengue Control, Sabin Vaccine Institute, University of Florida, World Health Organization (WHO)

Type of Partner(s) Academia / Hospitals, Government, IGOs, Multilaterals

Therapeutic Focus Neglected Tropical Diseases

Disease(s) Dengue

Program Type(s) Health System Infrastructure - Outreach & Medical Services, Health System Infrastructure - Training, Prevention Programs - Awareness & Outreach, Prevention Programs - Vaccines, Research & Development - Development of Treatments

Targeted Population(s) Children, Elderly, General population, Men, Mothers, People with low income, Women

Region(s) East Asia & Pacific

Number of Countries 10

Country(ies) Brunei, Cambodia, Indonesia, Lao PDR, Malaysia, Myanmar, Philippines, Singapore, Thailand, Vietnam

Research Country(ies) United States of America

Start Date 2010

More information Dengue Vaccine Study Press Release

Anticipated completion date Ongoing

« Sanofi Pasteur has supported the ASEAN Dengue Day initiative since its creation. In 2013, we are proud to play an increased role in contributing scientific knowledge about dengue disease through our vast vaccine research and development program. »

Dr. Joselito Sta. Ana, Senior Director, at Sanofi Pasteur Asia Pacific